An Effective Enzyme Solution to Histamine Intolerance and Imbalance. Alcoholic beverages - particularly red wine - present a triple threat to histamine sensitive people, because they contain histamine, they liberate histamine, and they block the action of DAO. Diamine oxidase (DAO) is your body’s first-line defense against histamine ingested through the diet or released within the gut. Take Omne Diem Direct Histamine Neutralizing Enzyme about 15-30 minutes prior to consuming high histamine foods and beverages, to help your body break down histamine and reduce the allergy-like reactions of histamine intolerance. Omne Diem Direct Histamine Neutralizing Enzyme is gluten-free, non-GMO, soy-free, non-dairy, food grade Diamine Oxidase - with no artificial preservatives or sweeteners.